TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
Aida Marcotti, Jorge Fernández-Trillo, Alejandro González, Marta Vizcaíno-Escoto, Pablo Ros-Arlanzón, Luz Romero, José Miguel Vela, Ana Gomis, Félix Viana, Elvira de la Peña Brain 146:475-491 doi: 10.1093/brain/awac273. Go to the post
Origins of direction selectivity in the primate retina
Yeon Jin Kim, Beth B Peterson, Joanna D Crook, Hannah R Joo, Jiajia Wu, Christian Puller, Farrel R Robinson, Paul D Gamlin, King-Wai Yau, Felix Viana, John B Troy, Robert G Smith, Orin S Packer, Peter B Detwiler, Dennis M Dacey Nature Communications 13:2862. doi: 10.1038/s41467-022-30405-5 (2022) Go to the post
Validation of six commercial antibodies for the detection of heterologous and endogenous TRPM8 ion channel expression
Pablo Hernández-Ortego, Remedios Torres-Montero, Elvira de la Peña, Félix Viana * and Jorge Fernández-Trillo * J. Mol. Sci. 2022, 23, 16164. (2022) Go to the post
The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature
Reimúndez A, Fernández-Peña C, Ordás P, Hernández-Ortego P, Gallego R, Morenilla-Palao C, Navarro J, Martín-Cora F, Pardo-Vázquez JL, Schwarz LA, Arce V, Viana F, Señarís R. Acta Physiol Oct 17:e13896. doi: 10.1111/apha.13896 (2022) Go to the post
Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2
Shuyong Zhu, Nancy Stanslowsky, Jorge Fernández-Trillo, Tamrat M Mamo, Pengfei Yu, Norman Kalmbach, Birgit Ritter, Reto Eggenschwiler, WernerJD Ouwendijk, David Mzinza, Likai Tan, Andreas Leffler, Michael Spohn, Richard JP Brown, Kai A Kropp, Volkhard Kaever, Teng-Cheong Ha, Pratibha Narayanan, Adam Grundhoff, Reinhold Förster, Axel Schambach,
Georges MGM Verjans, Manuela Schmidt, Andreas Kispert, Tobias Cantz, Ana Gomis, Florian Wegner, Abel Viejo-Borbolla Stem Cell Research S1873-5061(21)00382-2 Go to the post
Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function
Bastián Rivera, Claudio Moreno, Boris Lavanderos, Ji Yeon Hwang, Jorge Fernández-Trillo, Kang-Sik Park, Patricio Orio, Félix Viana, Rodolfo Madrid, María Pertusa. The Journal of Neuroscience 41:8475-8493 (2021) Go to the post
Detecting warm temperatures is a cool kind of thing
Gómez Del Campo A, Viana F Neuron 106, 112-114 (2020) Go to the post
Piezo2 mediates low-threshold mechanically-evoked pain in the cornea
Jorge Fernández-Trillo, Danny Florez-Paz, Almudena Iñigo-Portugués, Omar González-González, Alejandro González, Félix Viana, Carlos Belmonte and Ana Gomis The Journal of Neuroscience 40:8976-8993 (2020) Go to the post
Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits
Ordás Purificación, Hernández Pablo, Vara Hugo, Fernández-Peña Carlos, Reimúndez Alfonso, Morenilla-Palao Cruz, Guadaño-Ferraz Ana, Gomis Ana, Hoon Mark, Viana Félix, Señaris Rosa Journal of Comparative Neurology DOI. 10.1002/cne.24694 (2019) Go to the post
Characterization of TRPC Channels in a Heterologous System Using Calcium Imaging and the Patch-Clamp Technique
de la Peña E, Gomis A Methods in Molecular Biology. 1987:83-97 (2019) Go to the post
The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
Jose Miguel Arcas, Alejandro González, Katharina Gers-Barlag, Omar González-González, Federico Bech, Lusine Demirkhanyan, Eleonora Zakharian, Carlos Belmonte, Ana Gomis, Félix Viana The Journal of Neuroscience, 39:949-969 (2019) Go to the post
Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan
Aida Marcotti, Ana Miralles, Eduardo Dominguez, Eliseo Pascual, Ana Gomis, Carlos Belmonte, Elvira de la peña Pain 159:739-748 (2018) Go to the post
Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice
Alcalde I, Inigo-Portugues A, Gonzalez-Gonzalez O, Almaraz L, Artime E, Morenilla-Palao C, Gallar J, Viana F, Merayo-Lloves J, Belmonte C Journal of Comparative Neurology 526:1859-1874.(2018) Go to the post
Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice
Alfonso Reimúndez, Carlos Fernández-Peña, Guillermo García, Rubén Fernández, Purificación Ordás, Rosalía Gallego, Jose L Pardo-Vazquez, Victor Arce, Félix Viana, Rosa Señarís The Journal of Neuroscience 38:3643-3656 (2018) Go to the post
TRPA1 Channels Mediate Human Gingival Fibroblast Response to Phenytoin
López-Gonazález MJ, Luis E, Fajardo O, Meseguer V, Gers-Barlag K, Niñerola S, Viana F J Dent Res 96:832:839 (2017) Go to the post
A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons
Florez-Paz D, Bali KK, Kuner R, Gomis A Scientific Report 17;6:25923 (2016) Go to the post
TRPV1 channel modulation by hyaluronan reduces pain
de la Peña E, Gomis A, Ferrer-Montiel A, Belmonte C Channels 3:81-2 (2016) Go to the post
Caires R, Luis E, Taberner F, Fernández-Ballester G, Ferrer-Montiel A, Balazs E, Gomis A, Belmonte C and de la Peña E Nature communications 10.1038/ncomms9095 (2015) Go to the post
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice
Quallo T, Vastani N, Horridge E, Gentry C, Parra A, Moss S, Viana F, Belmonte C, Andersson DA, Bevan S Nature communications 6:7150 (2015) Go to the post
G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels
Imane Jemal, Sergio Soriano, Anna Lucia Conte, Cruz Morenilla and Ana Gomis Pflugers Arch - Eur J Physiol 466: 1635-46 (2014) Go to the post
Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation
Morenilla-Palao C, Luis E, Fernandez-Pena C, Quintero E, Weaver JL, Bayliss DA, Viana F Cell reports 8:1571-1582 (2014) Go to the post
Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain
Pertusa M, Gonzalez A, Hardy P, Madrid R, Viana F The Journal of biological chemistry 289:21828-21843 (2014) Go to the post
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
Meseguer V, Alpiza YA, Luis E, Tajada S, Denlinger B, Fajardo O, Manenschijn JA, Fernández-Peña C, Talavera A, Kichko T, Navia B, Sánchez A, Señarís R, Reeh P, Pérez-García MT, López-López JR, Voets T, Belmonte C, Talavera K, Viana F Nature Communications; 5:3125. doi: 10.1038/ncomms4125. (2014) Go to the post
Blockade of nociceptive sensory afferent activity of the rat knee joint by the bradykinin B2 receptor antagonist fasitibant
Gomis A*, Meini S*, Miralles A, Valenti C, Giuliani S, Belmonte C, Maggi CA Osteoarth. Cartilage 21:1346-54. (2013) Go to the post
Monoacylglycerols activate TRPV1 – a link between phospholipase C and TRPV1
Peter M. Zygmunt, Anna Ermund, Pouya Movahed, David A. Andersson, Charlotte Simonsen, Bo A.G. Jönsson, Bryndis Birnir, Stuart Bevan, Alain Eschalier, Christophe Mallet, Ana Gomis and Edward D. Högestätt PLoS One 8, e81618-32 (2013) Go to the post
Nociceptors: thermal allodynia and thermal pain
Viana F. Handb Clin Neurol 156:103-119 (2018) Go to the post
Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis
Señarís R, Ordás P, Reimúndez A, Viana F Pflugers Arch 470:761-777 (2018) Go to the post
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
Almaraz L, Manenschijn JA, de la Peña E, Viana F. Handb Exp Pharmacol. 222:547-79. doi: 10.1007/978-3-642-54215-2_22. (2014) Go to the post
Heat and cold pain
Viana F. and Voets T. The Oxford Handbook of the Neurobiology of Pain. John Wood (Ed.) Oxford University Press. ISBN: 9780190860509. (2019) Go to the post
Transient receptor potential cation cannel subfamily C member 5
Arcas J.M., Gomis A In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer Cham. (2018) Go to the post
TRP channels and mechanical transduction
Ana Gomis In: TRP channels in sensory transduction. Madrid, Bacigalupo Eds, Springer-Verlag. Berlin (Germany). P.141-164 (2015). Go to the post
Therapeutic effects of sodium hyaluronan derivatives (viscosupplementation) in experimental models of osteoarthritic pain
Gomis A In: “Pain Models: Translational relevance and Applications”. Editors: Herman O. Handwerker and Lars Arendt-Nielsen. IASP Press. P 247-261. ISBN: 978-0-931092-94-7. (2013) Go to the post